At Marie Veronique Organics we rely on our own diligent research, as well as the work of industry experts and skin care studies. Together, this body of research tells us what’s safe and what’s not, what works and what doesn’t. And now we want to let you in on it, too.
An update on the pathogenesis and management of acne vulgaris
Acne vulgaris is an easily recognizable dermatologic disease. It is also very common. Acne is seen in nearly 100% of individuals at some time during their lives. Small, noninflamed acne lesions may not be more than a slight nuisance but, in individuals with more severe inflammatory nodular acne, pain, social embarrassment, and both physical and psychological scarring can be life altering. Fortunately, our understanding of the pathogenesis of acne has progressed and our therapeutic armamentarium has greatly expanded in the last twenty-five years.
Benzoyl Peroxide Cautions and FDA Category Changes
Use of benzoyl peroxide to control acne may involve side effects and risks that should be considered in making decisions on acne treatment. BiON has given particular attention to providing effective treatment with no side effects and no benzoyl peroxide.
Effect of benzoyl peroxide on antioxidant status, NF-κB activity and interleukin-1α gene expression in human keratinocytes
These results demonstrate that BP induces an inflammatory reaction mediated by oxidative stress by a pathway independent of the redox-sensitive transcription factor NF-κB.
Pantothenic Acid, B5 for Acne
In this article we will present to you information about Vitamin B5 (pantothenic acid) as a treatment for acne. We will explain the role of Vitamin B5 in the metabolism of fats and oils, and how increasing the metabolism of oils will reduce oil accumulation in the skin, and thereby reduce or eliminate acne. Both Accutane and Vitamin B5 work by different mechanisms. Accutane works by shrinking the sebaceous glands at the root of the hair follicles. However, Vitamin B5 works by reducing the oil production of the sebaceous glands. This is done by increasing Coenzyme A (Co-A) which increases the metabolic breakdown of oils by normal activity of cell physiology.
How Pantothenic Acid Unveils the Mysteries of Acne Vulgaris and Obesity
In reviewing the numerous studies that deal with the pathogenesis of acne vulgaris, and one gets the impression of reading a detective story. There is the victim. The facts are all there. There are all the clues, as well as the suspects. But the culprit cannot be identified. The identification is made the more difficult because the clues seem all tangled up. At times, they fit in with the suspects very well, other times however, the same clues are contradictory, and appear to lead to a hopeless situation. In the same way, it is quite a mystery that an over-weight person, with an abundance of energy deposited as fat depot, cannot efficiently use this stored fat in times of need as during dieting when food intake does not meet the energy demand. Not only is this precious stored unavailable,I n some cases it is actually squandered.
Skin tumor-promoting activity of benzoyl peroxide, a widely used free radical-generating compound
A single topical application of benzoyl peroxide produced a marked epidermal hyperplasia and induced a large number of dark basal keratinocytes, effects similar to those produced by the potent tumor promoter 12-O-tetradecanoyl phorbol-13-acetate. Benzoyl peroxide, like other known tumor promoters, also inhibited metabolic cooperation (intercellular communication) in Chinese hamster cells.
Ultraviolet A radiation-induced biological effects in human skin
In this review, our current knowledge about the signal transduction pathway involved in UVA radiation-induced expression of proinflammatory genes relevant to the pathogenesis of polymorphous light eruption will be summarized.
Anti-aging Potential in Fat Molecule
Scientists in South Korea claim to have uncovered a fat molecule with strong anti-aging potential from tests on the ability of lipids to fight skin aging.
Free Radicals and Sunscreens
Does sunscreen save skin — or damage it? Study alarms some scientists, but don't deep-six your SPF just yet.
Resveratrol in prevention and treatment of common clinical conditions of aging
Resveratrol is a potent member of the class of natural, plant-derived chemicals known as polyphenols. These help explain in part why a diet high in fruit and vegetables confers health benefits and are associated with reduced risk of common complex conditions such as cardiovascular disease, cancer, diabetes, and Alzheimer’s disease.
Rosacea or Adult Acne?
Sensitive skin, rosacea, adult acne—how can you tell where you fit? A recent article in the New York Times by Camille Sweeney, “In a Perfect World, Rosacea Remains a Problem” suggests that rosacea has become “the new cellulite.”
UVA and aging -- the future of sun protection
The sun emits light at all different wavelengths, including x rays and radio waves, but 99% of its output is in the form of ultraviolet (UV), visible and infrared (IR) light.
UVA Protection as an Anti-aging Strategy: a ten point information guide
The following facts are summarized from an article by Sheldon R. Pinnell, MD and Doren L. Madey, PhD, which appeared in the peer-reviewed Aesthetic Surgery Journal...
Why Lipids and Sunscreen are Your Best Protection Against Dehydration, Aging and Breakouts
It is a truism in natural circles that your body does its best job fighting off disease and healing itself when it has the nutritional wherewithal to do so. This notion has even more applicability when it comes to treating your skin.
Long-Distance Retrograde
Effects of Botulinum Neurotoxin A
Why Darwin Would Have Loved Botox
The latest news on Botox is that it may actually shut down parts of the brain. This information comes from a recent article by Carl Zimmer, "Why Darwin Would Have Loved Botox."
Beta Glucan to Fight Aging
The fight against aging has received a scientific boost thanks to an innovative study done in part by a University of Alberta spin-off company--research that dispels a hard-held belief about the natural ingredient, beta glucan.
* NEW * Chitin-Glucan, Natural Cell Scaffold for Skin Moisturization and Rejuvenation
In conclusion, the chitin–glucan formulations appear safe. They significantly mitigate some signs of skin ageing and improve both stratum corneum hydration and skin barrier function.
* NEW * Chitin-Nanofibrils: A New Active Cosmetic Carrier
At this purpose, active compounds of new cosmetic products has to be carefully selected to obtain the best efficacy and safeness. Thus innovative cosmetics have become more sophisticated in both formulations and presentation meanwhile new tests have been developed to ensure not only quality and safety but also the validation of products claims.
Coffee Berry Extracts
CoffeeBerry will be recognized for the first time as a powerful antioxidant for the thriving skin-care market at The American Academy of Dermatology's annual meeting in February.
Glucosamine and Anti-Aging
The American Academy of Dermatology says that a recent study shows that glucosamine could prove to be an effective topical treatment to reverse the effects of skin cells damaged by UV exposure.
Green Tea Extract Protection Against UV Damage: Study
Topical application of low dose green tea extract may help protect against UV damage, without the common side effects.
Guarana Extract
Extracts from the exotic fruit guarana showed excellent antioxidant and antibacterial properties, which could see the exotic berry making a move into cosmetics, new research suggests.
Hyaluronic Acid
The skin matrix is what would remain if you took the dermis (the fibrous middle layer of the skin) and removed all cells from it. The skin matrix is responsible for structural integrity, mechanical resilience, stability and many other properties of the skin
Inhibition of Oxidative Injury of Biological Membranes by Astaxanthin
The value of astaxanthin, a carotenoid pigment, in the treatment of oxidative injury is assessed. Astaxanthin protects the mitochondria of vitamin E-deficient rats from damage by Fe2(+)-catalyzed lipid peroxidation both in vivo and in vitro.
Influence of flavonoids and vitamins on the MMP
Influence of flavonoids and vitamins on the MMP and TIMP-expression of human dermal fibroblasts after UVA irradiation.
Lactic Acid for Natural Anti-Aging, Skin Lightening and Anti-Acne
Lactic acid is being discovered all over again, as new nformation emerges showing that it useful as a probiotic in anti-acne treatments. Lactic acid is the gentlest of the alpha hydroxy acids; it is also very versatile and has great utility in treating a number of different skin conditions. These three posts look at the benefits of LA from three different points of view: anti-aging, skin lightening and anti-acne.
Niacinamide: an anti-aging powerhouse
The track record of topical vitamins in skin rejuvenation has been mixed at best. A few, such as vitamins A and C, do provide some benefits if properly stabilized and applied in sufficient concentrations. It appears that another vitamin, niacinamide, should be added to this select group.
PLE Mediation with AGR
Background: Polymorphous light eruption (PLE) is the most common photodermatosis. While its etiology still remains elusive, pathogenesis seems to involve UVA-induced oxidative stress and subsequent deregulation of antioxidative immune responses.
Polypodium leucotomos and Sun Protection
Topical or oral administration with an extract of Polypodium leucotomos prevents acute sunburn and psoralen-induced phototoxic reactions as well as depletion of Langerhans cells in human skin.
Sun-Protected Skin and Collagen Synthesis
Estradiol may stimulate collagen levels in sun protected skin. Topical estradiol can induce collagen synthesis but only in skin not exposed to sunlight, according to a recent study from scientists in Michigan.
Titanium Dioxide: Toxic or Safe?
Titanium dioxide is the subject of new controversy, yet it is a substance as old as the earth itself. It is one of the top fifty chemicals produced worldwide. It is a white, opaque and naturally- occurring mineral found in two main forms: rutile and anatase.
Alarming Results From New Study Supports Concerns About Use Of TiO2 Nanoparticles in Personal Care Products
Scientists at the University of Plymouth have shown, for the first time in an animal, that nanoparticles have a detrimental effect on the brain and other parts of the central nervous system.
Benefits of Topical l-ascorbic acid
Ascorbic acid is a water soluble alpha hydroxy acid (AHA) that functions as an antioxidant and a required chemical for several metabolic reactions. It occurs naturally in plants particularly in fruits and some animals are able to synthesize this vitamin.
FDA takes ‘first step’ toward greater regulatory certainty around nanotechnology
The U.S. Food and Drug Administration today released draft guidance to provide regulated industries with greater certainty about the use of nanotechnology, which generally involves materials made up of particles that are one billionth of a meter in size. The guidance outlines the agency’s view on whether regulated products contain nanomaterials or involve the application of nanotechnology.
Discussion paper on nanotechnology standardisation and nomenclature issues
Friends of the Earth Australia recommends defining nanoparticles as ‘particles having one or more dimensions measuring approximately 0.3 nanometres (nm) to 300 nm, or particles which have structures that exist at this scale’ for the purposes of health and safety assessment.
Lipid nanoparticles mediated cell uptake of resveratrol
That was prevented by loading it into solid lipid nanoparticles, which preserved cell morphology. The cytostatic effect of SLN–RSV was much more expressed than that of RSV in solution. Delivery of RSV by SLN contributes to effectiveness of RSV on decreasing cell proliferation, with potential benefits for prevention of skin cancer.
Plastic Nanoparticles Can Move From Mom to Baby Through Placenta
Research shows for the first time that plastic nanoparticles can cross the human placenta, possibly exposing the developing fetus to the tiny materials that are increasingly used in medicines, vaccines and personal care products.
Obama’s EPA Poised To Crack Down on Nanotech
Under agency chief Lisa Jackson, the Obama Administration’s Environmental Protection Agency has promised to tighten regulations on nanomaterials, particles as small as molecules which are used by companies working in fields as varied as cosmetics and advanced materials.
Absorption of Zinc Nanoparticles in Sunscreen
It looks like some independent research on sunscreens is turning up some interesting findings. According to The Australian, “Geochemist Brian Gulson, of Sydney's Macquarie University, has provided the first conclusive evidence that zinc oxide nanoparticles...
Amid Nanotech's Promise, Health Risks Grow
For almost two years, molecular biologist Bénédicte Trouiller doused the drinking water of scores of lab mice with nano-titanium dioxide, the most common nanomaterial used in consumer products today.
Brian Gulson Research Study on Nanoparticles
Independent research on sunscreens is turning up some interesting findings. According to The Australian and ABC “Geochemist Brian Gulson, of Sydney's Macquarie University, has provided the first conclusive evidence that zinc oxide nanoparticles...
Nanoparticles can cause DNA damage across a cellular barrier
The increasing use of nanoparticles in medicine has raised concerns over their ability to gain access to privileged sites in the body. Here, we show that cobalt–chromium nanoparticles (29.5 6.3 nm in diameter) can damage human fibroblast cells...
Nanoparticles Damage DNA Remotely: Study
Nanoparticles used in medical applications can indirectly damage DNA inside cells by transmitting signals through a protective barrier of human tissue, says UK researchers.
MVO Particle Size Profile
A US Consumer’s Union series of investigations prompted them to write a letter to the FDA asking that the organization require a full safety assessment on the use of nanoparticles in cosmetics, sunscreens and sunblocks before a product is allowed to market.
Nano-Sunscreens Leave Their Mark
Painted metal roofs are cheap, convenient, and usually very durable. But over the past two years, a rash of accelerated ageing has blighted pre-painted steel roofing in Australia.
New Products Bring Side Effect: Nanophobia
It sounds like a plot straight out of a science-fiction novel by Michael Crichton. Toiletry companies formulate new cutting-edge creams and lotions that contain tiny components designed to work more effectively.
Sun's Rays May Leave Mysterious Marks
For adults and children alike, summer is the season to take in the mystery of the outdoors, its unexpected pleasures and hidden thrills. But summer has its share of unpleasant discoveries, too — as dermatologists know all too well. For this is also the season of the mystery rash. "This time of year, a lot of people come in with rashes and have no idea what happened," said Dr. Deborah S. Sarnoff, a dermatologist in New York.
Active ingredients in sunscreens act as topical penetration enhancers
Agricultural workers are encouraged to use sunscreen to decrease the risk of UV-related skin cancer. Our previous studies have shown certain commercial sunscreens to be penetration enhancers.
Ultraviolet A radiation-induced biological effects in human skin: relevance for photoaging and photodermatosis
There is increasing evidence that longwave ultraviolet (UV) radiation (UVA; 320–400 nm) plays an important role in the pathogenesis of photodermatoses such as polymorphous light eruption as well as photoaging.
Current Sunscreen Controversies: A Critical Review
Sunscreens are believed to be a valuable tool in providing photoprotection against the detrimental effects of UV radiation, a known carcinogen. However, a number of controversies have developed regarding their safety and efficacy. This review summarizes the relevant studies surrounding these controversies.
Microfine Zinc Oxide is a Superior Sunscreen Ingredient to Microfine Titanium Dioxide
We compare microfine zinc oxide and microfine titanium dioxide for their abilities to attenuate UVA radiation and their relative whiteness in cosmetic formulations.
Reactive oxygen species produced upon photoexcitation of sunscreens containing titanium dioxide (an EPR study)
The generation of reactive oxygen radical species upon irradiation of sunscreens significantly depends on their composition, as the additives present (antioxidants, radical-scavengers, solvents) can transform the reactive radicals formed to less harmful products.
Chemical oxidation and DNA damage catalysed by inorganic sunscreen ingredients
Using chemical methods, we show that all sunscreen TiO2 samples tested catalyse the photo-oxidation of a representative organic substrate (phenol). We also show that sunlight-illuminated TiO2 catalyses DNA damage both in vitro and in human cells. These results may be relevant to the overall effects of sunscreens.
Epidemiological Support for an Hypothesis for Melanoma Induction Indicating a Role for UVA Radiation
An hypothesis for melanoma induction is presented: UV radiation absorbed by melanin in melanocytes generates products that may activate the carcinogenic process. Products formed by UV absorption in the upper layers of the epidermis cannot diffuse down as far as to the melanocytes.
Microfine zinc oxide (Z-Cote) as a photostable UVA/UVB sunblock agent
Microfine zinc oxide is an effective and safe sunblock that provides broad-spectrum UV protection, including protection from long-wavelength UVA.
Small Amounts of Zinc from Zinc Oxide Particles in Sunscreens Applied Outdoors Are Absorbed through Human Skin
Metal oxide nanoparticles are commonly used in personal-care formulations as protective agents against exposure to ultraviolet radiation. Although previous research has concluded that nanoparticles do not penetrate healthy skin, it remains contentious whether this conclusion holds under normal conditions of sunscreen use.
Sunscreen penetration of human skin and related keratinocyte toxicity after topical application.
Sunscreen skin penetration and safety assessment should be considered together in order to ensure that in vitro cytotoxicity studies examine relevant doses of these organic chemical UV filters to which viable epidermal cells are realistically exposed.
Sunscreen titanium dioxide nanoparticles on DNA
Most importantly, sunlight-illuminated sunscreen TiO2 particles catalyze DNA damage both in vitro and in human cells (FEBS Letters, 418 (1997)87). These results raise concerns on the overall effects of sunscreens and raise the question on the suitability of photoactive TiO2 as a sunscreen component without further studies.
Toxicity and penetration of TiO2 nanoparticles in hairless mice and porcine skin after subchronic dermal exposure
The present study investigated the penetration and potential toxicity of titanium dioxide (TiO2) nanoparticles following its dermal exposure in vitro and in vivo. In vitro, after exposure to isolated porcine skin for 24 h, titanium dioxide nanoparticles of carious sizes cannot penetrate through stratum corneum.
Potential photocarcinogenic effects of nanoparticle sunscreens
Titanium dioxide and zinc oxide nanoparticles are being increasingly formulated in sunscreens. While the same compounds, in larger particle form, work by reflecting UV radiation, in nanoparticle form, they absorb UV radiation, resulting in photocatalysis, releasing reactive oxygen species.
